The presence of Helicobacter pylori in colorectal polyps...

Pediatr Infect Dis J. 2012 Apr;31(4):364-7.

Cheng H, Zhang T, Gu W, Shu X, Zhang Y,Zhang X, Wu X, Chen J, Jiang M.

Source

Children's Hospital, ZhejiangUniversity Schoolof Medicine, Hangzhou, People's Republic of China.

Abstract

AIM:四川省第四人民医院消化内科常玉英

Polyps are a common cause of hematocheziain children, but the pathogenesis of polyps is unclear. The aim of this studywas to investigate the relationship between Helicobacter pylori (HP) infectionand colorectal polyps in children.

METHODS:

Thirty-five patients who had undergonepolypectomy after the detection of polyps served as the case group.Twenty-seven patients with gastrointestinal symptoms and normal colonoscopyserved as the control group. Hematoxylin and eosin (HE) stains obtained fromparaffin blocks were evaluated and classified according to histopathologic typeand degree of dysplasia. The other sections were used to detect HP organismsfor immunohistochemistry (IHC). The seroprevalence of HP antibodies in childrenwith colorectal polyps was detected by protein chip technology. HP infectionwas diagnosed if the serum urease antibody was positive.

RESULTS:

The HP-positive rate in children withcolorectal polyps was 57.1% (20/35), which was higher than the rate of 22.2%(6/27) for colonic mucosa in the control group (P < 0.01). The differencesin the presence and absence of HP infection between patients with juvenilepolyps and juvenile polyposis syndrome were not statistically significant. Age,gender, and the number, size, and locations of the colonic polyps were notsignificantly different between the patients with HP-positive and HP-negativepolyps. The HP-antibody-positive rate was 65.0% (13/20) in the patients withHP-infection-positive colorectal polyps, which was higher than the rate of 26.7%(4/15) for the patients with HP-infection-negative colorectal polyps (P <0.05).

CONCLUSION:

Our findings suggest a positive associationbetween HP infection and colorectal polyps in children in this study,indicating that HP infection is a risk factor for colorectal polyps inchildren.